NLRP3 and systemic lupus erythematosus: For instance, U1-snRNP was found to be responsible for persistent fatigue and dyspnea (p = 0.02) and led to the emergence of post-COVID systemic lupus erythematosus (SLE) by activating the nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP3) inflammasome and inducing IL-1β production [45].