To summarize, the obtained results clearly indicated that the tested DS variants could rapidly influence the actin cytoskeleton organization in breast cancer cells, which suggests the impact of these glycans on the activity of at least two small Rho GTP-ases, i.e., Rac1 and Cdc42, which are responsible for the formation of the lamellipodia and filopodia, respectively [15]. Here, RHO is linked to breast cancer.