In the present study, we first tested whether NF and PM, when used at the same concentration, could also rapidly trigger the phosphorylation of MLKL in another primary luminal breast cancer cell line, i.e., BT-474, and then we addressed the precise time course not only of this process but also of the one that was induced by DF or PM in the T-47D line. This evidence concerns the gene MLKL and breast cancer.