Aβ peptides generated by the sequential proteolysis of amyloid precursor protein (APP) by β- and γ-secretases are particularly prone to aggregation [6,7], resulting in plaques that contribute to tau pathology, neuroinflammation, synaptic dysfunction, neurodegeneration, and cognitive decline [8,9,10,11,12,13]. The gene discussed is APP; the disease is Mental deterioration.