Moreover, the interaction between melanoma cells and the TME has been shown to result in increased production of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF), interferon gamma (IFN-γ), and many more [18]. This evidence concerns the gene TNF and melanoma.