Furthermore, upregulation of SP1 was also observed in recent studies, where it interacted with KLF5, lncRNA CTBP1-AS2, SYHE1-AS1, PCDH17, SNHG14, and PED5 promoter regions to influence cardiac hypertrophy development [53,54,55,56,57]. The gene discussed is SP1; the disease is cardiac hypertrophy.