How these potential DDX3X targets are regulated is not clear; however, Brown et al. compared the relative translation of luciferase reporters with structured and unstructured 5′ UTRs, respectively, in the medulloblastoma-associated ded1 mutants in yeast and found that virtually all the mutants had defects in translating mRNAs with more structured 5′ UTRs [70]. The gene discussed is DDX3X; the disease is medulloblastoma.