While the TGF-β1-stimulated HSC cell line is a useful and widely accepted model to explore the mechanisms of fibrosis, screen for therapeutic agents, and understand the cellular responses to fibrogenic stimuli, our findings need to be complemented with in vivo studies to fully understand the effects of the compounds in the context of the complexities of liver fibrosis. This evidence concerns the gene TGFB1 and Hepatic fibrosis.