PDGFRB and autosomal recessive polycystic kidney disease: Then, the researchers showed that three PDGFR tyrosine kinase inhibitors (imatinib, sunitinib and crenolanib) exhibited anti-fibrotic effects on the ARPKD-like organoids [56], proving that the PDGFRB pathway contributes to the formation of fibrosis in ARPKD-like organoids.