NR1H4 and neoplasm: Compared with previous cell models, organoids have some advantages, including potent mitochondrial respiration, enhanced expressions of genes involved in bile acid synthesis, bile acid receptors and transporters [28], remarkable CYP450 activity [99], hepatitis model construction and support of the full replication cycle of hepatitis virus [81,83,84], and high preservation of original tumor characteristics [39,47,49,69,79].