As mentioned earlier, molecules such as UBE2T, E3 ubiquitin ligase adaptor SPOP, USP9X, USP22, and BAP1 are involved in regulating the proliferation, migration, and invasion of osteosarcoma cells through modulation of the PI3K/Akt signaling pathway [53,93,97,105]. The gene discussed is USP22; the disease is osteosarcoma.