According to recent research reports, DUBs mainly comprise seven families: the cysteine proteases of the USP (ubiquitin-specific proteases), UCH (ubiquitin C-terminal hydrolases), OTU (ovarian tumor), MJD (Machado–Joseph domain-containing proteases), MINDY (motif interacting with the Ub-containing novel DUB family), and ZUFSP (zinc finger with the UFM1-specific peptidase domain protein) families, and the zinc-dependent metalloproteases of the JAMM (JAB1/MPN/MOV34 domain-associated) family [15]. The gene discussed is ZUP1; the disease is ovarian neoplasm.