PTPN11 and Other metabolic disease: In the review on the clinical relevance of circulating non-coding RNAs in metabolic diseases (such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome), Dandare cites that miRNA-138 suppresses adipogenic differentiation and is implicated in obesity by interaction with a potent inhibitor of adipogenic differentiation that interferes with Src homology region 2-containing protein (SHP2), an endogenous enhancer of adipogenic PPARγ [208].