Because, in the MetS group, there were both women with prediabetic stage and female patients with type 2 diabetes, it is possible the stabilized level of this adipokine in serum was connected with the fact observed by Ussar et al. [3] that, in prediabetic subjects, the glypican-4 level is elevated, but in patients with type 2 diabetes it is decreased, in comparison with healthy persons. Here, GPC4 is linked to type 2 diabetes mellitus.