Accordingly, Cugno et al. [69] also found higher levels of plasmatic markers of thrombin generation and fibrinolysis, including prothrombin fragment F1+2, activated F7, thrombin-antithrombin complex and D-dimer, and fibrinogen/fibrin degradation products (FDP), in patients with chronic spontaneous urticaria, angioedema, and bullous pemphigoid. This evidence concerns the gene F2 and angioedema.