Significant changes were also detected in several proteins implicated in cell adhesion as well as cell-surface-mediated signaling, including Integrin beta-3 (ITB3) [FC = 0.50; p = 0.006], transforming growth factor-beta-induced protein IG-H3 (BGH3) [FC = 2.6; p = 0.001] and Desmocollin-2 (DSC2) [FC = 3.9; p = 0.001] in donors with lichen, or 4F2 cell-surface antigen (4F2) [FC = 0.44; p = 0.008] and myotrophin (MTPN) [FC = 8.8; p = 0.005] in individuals with psoriasis. This evidence concerns the gene CD53 and lichen disease.