Interestingly, RNA sequencing data from the Splice-O-Mat platform showed that hH3R-445, hH3R-453, hH3R-373, hH3R-399a, hH3R-399b, hH3R-269, and hH3R-56 were expressed at higher levels in the brains of individuals with an opioid use disorder (OUD) or Alzheimer’s disease symptoms as compared to the control population (Figure 2). The gene discussed is HRH3; the disease is early-onset autosomal dominant Alzheimer disease.