Zaytouni et al. found that AGR2 expression was increased in obese PDAC patients and AKT-driven PDAC patients, the invasiveness of pancreatic cancer cells was proportional to the level of AGR2 expression [42,117,118], and the silencing of AGR2 in human pancreatic cancer cells (MPanc-96) inhibited tumor growth [42]. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.