FGF2 and neoplasm: AGR2 secreted by ovarian cancer not only sustains tumor growth by regulating the protein cycle and modulating fibroblasts but also acts as a chaperone protein binding to extracellular signaling molecules [75], enhancing its own activity and promoting angiogenesis and tumor growth, including factors like vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) [76].