At the same time, immunohistochemical staining of the tumor tissues in different groups treated with lumbrokinase and/or chemotherapeutics showed that compared with the control group, the expressions of COX-2, phosphorylated AKT and Erk, β-catenin, and Bcl-2, and the location of p50 and p65 in the nucleus, were all decreased upon treatment, and this reduced trend was more pronounced in the combined group (Figure 7G). This evidence concerns the gene NFKB1 and neoplasm.