Similarly, Western blot assay of tumor tissues in different groups also showed that the expressions of COX-2, p-Erk, Erk, p-AKT, and Bcl-2 were markedly decreased upon the combinational treatment of lumbrokinase with vincristine or paclitaxel, compared to the single agent treatment, but the expression of the total AKT remained nearly unchanged (Figure 7H). The gene discussed is AKT1; the disease is neoplasm.