Since lumbrokinase simultaneously inhibited PI3K/AKT and MAPK/ErK signaling pathways in NSCLC cells based on the above results and growth factors function as the common upstream molecules of these two signaling pathways, we speculate that lumbrokinase is highly likely to act on the upstream of these two pathways and influence the expression of some growth factors. Here, AKT1 is linked to non-small cell lung carcinoma.