VEGFA and neoplasm: Considering the important role of BPTF in tumor progression as a ubiquitously expressed ATP-dependent chromatin-remodeling factor according to the reports in recent years [51,52,53,54,55], our study not only revealed the anti-tumor effect of lumbrokinase, which is at least partially realized by targeting BPTF, but also uncovered the underlying molecular mechanisms of lumbrokinase in regulating VEGF expression.