Hypopituitarism, especially when partial, can remain asymptomatic for a long time and manifest later [23]; this is the case, for example, with short stature due to growth hormone deficiency [24], in which damage to somatotropic cells may not cause acute alterations but can manifest with reduced growth velocity and loss of height percentiles [23]; other possible manifestations are seizures or hypoglycemia [25] and, during adulthood, reduced female fertility due to decreased maturation of granulosa cells and reduced modulation of FSH and LH [26]. This evidence concerns the gene PLOD1 and hypopituitarism.