TSH deficiency causes central hypothyroidism [28], usually symptomatic with the onset of lethargy, fatigue, weight gain, and metabolic manifestations such as hypercholesterolemia, while prolactin deficiency and/or hypersecretion, despite their relationship with growth hormone secretion, is often asymptomatic in pediatric age [29]. This evidence concerns the gene GH1 and central congenital hypothyroidism.