For example, no studies were found providing cephalometric data for individuals with mutations in the Aggrecan (ACAN) gene located on 15q26, which causes spondyloepimetaphyseal dysplasia aggrecan type (OMIM 612813), spondyloepiphyseal dysplasia type Kimberley (OMIM 608361), and short stature with advanced bone age (OMIM 165800). Here, ACAN is linked to spondyloepiphyseal dysplasia, Kimberley type.