PTX3 and obesity due to melanocortin 4 receptor deficiency: Univariate regression analysis showed that hypertension (OR 15.2), diabetes (OR 7.05), and obesity (OR 4.14) are the most significant predictors of CXR infiltrate severity, together with ACE D/D polymorphism (OR 3.58) and PTX3 serum level (OR 1.26).