PARP1 and neoplasm: The notion of PARP1 playing a role in cellular function beyond its role in DNA damage repair is underscored by a genome-wide CRISPR loss-of-function screen of over 1000 cell lines (https://depmap.org/portal/, accessed on 9 July 2024, including only those tumor lineages with at least 10 characterized cell lines) that suggests that PARP1 dependency across different tumor types is relatively comparable (Figure 2A).