PKP2 and arrhythmogenic right ventricular cardiomyopathy: ARVC is typically an inherited condition linked to pathogenic gene variants mainly in desmosome-related genes, including PKP2 (plakophilin-2), DSP (desmoplakin), DSG2 (desmoglein-2), and DSC2 (desmocollin-2), though occasionally in non-desmosome genes as well [88].