NLRP3 and in situ carcinoma: In studies that examined the efficacy of H2 against peripheral neuropathy induced by CIS and OXA [38,39], cardiotoxicity and hepatotoxicity induced by DXR [40], and lung injury induced by BLM [42,43], H2 reduced NLRP3 protein levels, LPS and TLR4 expression levels, and TNF-α, IL-1β, and IL-6 levels, respectively, which were increased by these anticancer drugs.