On the other hand, in studies that investigated the efficacy of H2 against CIS-induced ototoxicity [34], ovarian injury [37], and peripheral neuropathy [38], DXR-induced cardiotoxicity and hepatotoxicity [40], and BLM-induced lung injury [42], H2 reduced MDA, 8-iso-PGF2α, and 4-HNE levels, which were increased by the side effects of these anticancer drugs, and also enhanced the activities of SOD, CAT, HO-1, and GSH-PX, which were decreased by these anticancer drugs. This evidence concerns the gene HMOX1 and in situ carcinoma.