Indeed, CAFs recruit immune cells and activate angiogenesis by secreting a variety of growth factors (e.g., TGF-β and VEGF), cytokines (e.g., IL-6), chemokines, extracellular vesicles, and extracellular matrix components (e.g., collagen and MMPs) that play a crucial role in tumour growth [183,185]. The gene discussed is TGFB1; the disease is neoplasm.