The involvement of PAK4 in anoikis resistance was confirmed by its experimental silencing, which led to increased anoikis and inhibition of glioma cell invasion and migration through downregulation of metalloprotease 2 (MMP2), alpha-v beta-integrin (Avß3) and epidermal growth factor receptor (EGFR) [168]. This evidence concerns the gene PAK4 and central nervous system cancer.