These PRGs, which are upregulated in gliomas, include caspase-3 and caspase-9, n-terminally truncated gasdermin D (GSDMD), and the inflammasome proteins NLRP2 (“NLR family pyrin domain containing 2”) and NLRC4 (“NLR family CARD domain containing 4”). The gene discussed is GSDMD; the disease is central nervous system cancer.