SLC7A11 and neoplasm: A trigger function for ferroptosis was discovered for erastin, which acts as an inhibitor of the cysteine/glutamate antiporter system Xc- with its main component solute carrier family 7 member 11 (SLC7A11), leading to an inhibition of the antioxidant defense mechanisms of the tumor cells and cell death of several RAS-mutated tumor cell lines [11].