Two important examples are the plant-derived flavonoid, kaempferol, which leads to induction of autophagy and pyroptosis of glioma cells [99], and the plant-derived cytokine N6-isopentenyladenosine (iPA), which leads to activation of RIPK1, RIPK3, and MLDL, with subsequent induction of necroptosis [116]. Here, RIPK3 is linked to central nervous system cancer.