Other molecular pathways that can lead to the stimulation of RIPK3 and subsequent necroptosis are the activation of interferon γ-receptors (IFN-γ), toll-like-receptors 3 and 4 (TLR3/4), as well as viral infections leading to activation of the Z-DNA binding protein 1 (ZBP1) (Figure 4) [19,105,106]. Here, ZBP1 is linked to viral infectious disease.