AKT1 and autoimmune disease: Furthermore, consistent with the AKT1/mTOR pathway regulating IL-17 in various autoimmune diseases, the miR-let-7d-3p knockout increased IL-17 levels via the AKT1/mTOR pathway, and co-overexpressing AKT1 with miR-let-7d-3p recovered IL-17 expression [28].