And protective causality for the impact of CD3 on naive CD8+ T cells (IVW OR = 0.7530, 95% CI = 0.5997 to 0.9456, p < 0.05) and CD3 on Naive CD4+ T cells (IVW OR = 0.8041, 95% CI = 0.6469 to 0.9996, p < 0.05) on liver cancer were revealed (Figure 5 and Supplementary Table S8). Here, CD8A is linked to liver cancer.