In this study, we confirmed that CXCR2−/− mice fail to recruit neutrophils to the brain in a murine SE model from LPS-induced sepsis, but there is a similar level of adhesive neutrophils on the surface of cerebral endothelial cells, which is also verified by CXCR2 inhibitor SB225002. Here, CXCR2 is linked to Sepsis.