Twenty-six athletes were chronically taking thyroid hormones due of clinical problems (19 were affected by hypothyroidism, 2 underwent total thyroidectomy, 4 suffered from Hashimoto’s thyroiditis, and 1 suffered from Basedow’s disease) In addition, 85 athletes showed TSH values out of the normal range: only 1 clinically manifested hypothyroidism (with elevated TSH and reduced ft4); 84 athletes were affected by sub-clinical hypothyroidism. The gene discussed is TG; the disease is Hashimoto thyroiditis.