GSK3B and malignant colon neoplasm: Our previous study demonstrated that the parecoxib antimetastasis mechanism effect is correlated with the attenuated phosphorylation of Akt, the expression of vimentin (a mesenchymal marker), and β-catenin, and corresponds with the up-regulated GSK3β and E-cadherin (an epithelial marker) in human colon cancer cells [24].