For instance, rare mutations in RIPK1, such as D324N, D324H, and D324Y at the Caspase-8 recognition site LQLD, block Caspase-8-mediated cleavage of RIPK1, resulting in an autosomal-dominant autoinflammatory disease, characterized by recurrent fevers and lymphadenopathy [114,115,116]. Here, RIPK1 is linked to Lymphadenopathy.