TNFAIP3 and multiple sclerosis: For instance, monogenic mutations in genes such as IKBKG (encoding NEMO), TNIP1 (encoding ABIN1), TNFAIP3 (encoding A20), and members of the LUBAC complex have been linked to auto-immune and inflammatory disorders, such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, and multiple sclerosis [117,118,119,120].