SGSH and mucopolysaccharidosis type 1: Depending on the type of disease in the clinical trials analyzed, the genes encoding IDUA (iduronidase) conditioning the degradation of heparan sulfate (HS) and heparan dermatan (DS) was administered, SGSH (sulfamidase) conditioning the degradation of heparan sulfate (HS), NAGLU (N-α-acetylglucosaminidase) conditioning the degradation of heparan sulfate (HS) in the treatment of MPSI, MPSIIIA, MPSIIIB, respectively.