AKR1C4 and colorectal carcinoma: As group of authors suggested, linoleic acid and 12 hydroxy 8,10-octadecadienoic acid, serum M2-pyruvate kinase and six metabolic genes (NAT2, XDH, GPX3, AKR1C4, SPHK1, and ADCY5) expression represent possible biomarkers for early detection and transition to CRC condition, emphasizing the significance of metabolism reprogramming in IBD and CRC [165].