In previous research, the focus was primarily on investigating the role of individual oncogenes, such as p53 [8], SOX2 [9], MALAT1 [10], IGF-2 [11], cyclin E1 [12], C3AR1 [13], and ATG16L1 [14], as single hub genes in osteosarcoma (OS). Here, C3AR1 is linked to osteosarcoma.