CD4 and melanoma: Additionally, Gal-1 blockade has been reported to induce the positive regulation of CD4+ and CD8+ T-lymphocyte tumor infiltrates in pancreatic adenocarcinoma, head and neck carcinoma, melanoma, neuroblastoma, lung adenocarcinoma, ovarian carcinoma, and breast carcinoma [52,55,78,81,82,83,84].