The aberrant expression of Gal-1 has been described in various tumor tissues, including GC, ovarian carcinoma, hepatocellular carcinoma (HCC), colon carcinoma, renal cell carcinoma, breast carcinoma, cholangiocarcinoma, squamous cell carcinoma of the head and neck, lung carcinoma, urothelial carcinoma, prostate carcinoma, Kaposi’s sarcoma, Hodgkin lymphoma, and glioblastoma multiforme, often associated with poor survival [47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68]. This evidence concerns the gene LGALS1 and head and neck squamous cell carcinoma.