Cytoskeleton: Among the cytoskeletal proteins, not only the microtubules as direct targets for Vinca alkaloids, taxanes, and new drug candidates are well-known [139] but also others, such as actin, vimentin, and cytokeratin as well as proteins accompanied by cytoskeletal proteins that contribute to cytoskeletal organization and basic tumor cell features (e.g., cell remodeling during invasion and metastasis, resistance to cisplatin and other drugs, etc.)[140,141,142]. Here, VIM is linked to neoplasm.