Several other genes also play a significant role in the development of AMD, including complement factor B (CFB), complement component 2 (C2), the cluster of differentiation 46 (CD46) protein, complement factor I (CFI), ATP-binding cassette transporter A1 (ABCA1), matrix metalloproteinase 9, cholesterol ester transfer protein (CETP), tissue inhibitor of metalloproteinase 3 (TIMP3), and superoxide dismutase 2 (SOD2) [9]. The gene discussed is TIMP3; the disease is age-related macular degeneration.