HTRA1 and age-related macular degeneration: Multiple research efforts have established a strong correlation between AMD and variations in both coding and non-coding regions of the complement factor H gene (CFH) located on chromosome 1q31 as well as the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement A serine peptidase 1 (HTRA1) genes on chromosome 10q26 [17,18,19].