While Grassman et al.’s analysis emphasized the importance of variants within the ARMS2 gene in contributing to AMD risk, Dewan et al.’s research did indeed find an association between AMD and the HTRA1 promoter polymorphism, suggesting that HTRA1 may still play a role in the predisposition to AMD, albeit possibly secondary to ARMS2 [87]. The gene discussed is HTRA1; the disease is age-related macular degeneration.