SYN3 and age-related macular degeneration: Chen et al. performed a GWAS scan in 2157 AMD cases and 1150 controls and found that, apart from already established susceptibility loci (e.g., CFH, ARMS2, C2/CFB, and CFI), alleles at the rs9621532 locus near the SYN3/TIMP3 gene on chromosome 22 are associated with an increased risk of AMD [113].