HSP90AA1 and metabolic dysfunction-associated steatotic liver disease: A novel USP14-HSP90AA1-CYP2E1 axis contributing to NAFLD pathogenesis was reported by Wei et al. In vitro and in vivo data show that ubiquitin-specific proteinase 14 overexpression inhibits the degradation of heat shock protein 90 alpha family class A member 1, resulting in increased CYP2E1 protein levels [175].