In HCC, evaluation of the CYP4 family expression profile in 377 cases from The Cancer Genome Atlas datasets revealed that high CYP4F12, CYP4V2, and CYP4F2 mRNA expression levels were negatively correlated with cell cycle-related genes and positively correlated with better overall survival, suggesting that these CYP4 genes are favorable prognostic markers in HCC patients [240]. This evidence concerns the gene CYP4F12 and hepatocellular carcinoma.