DVL2 and hepatocellular carcinoma: CYP1A2 is also able to suppress HCC tumorigenesis by inhibiting the Wnt/β-catenin signal, reducing Dvl2 (a core component of Wnt signaling) expression by inducing its interaction with an E3 ubiquitin kinase, leading to its degradation, and promoting the accumulation of reactive oxygen species [236].