Although it is important to note that [11C]PBB3 may capture a greater range of tau conformers [39,70], clinical studies showed that [18F]AV-1451 has higher sensitivity than [11C]PBB3 in detecting tau pathology in Alzheimer’s disease and frontotemporal dementia patients at both a group and an individual level [39]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.