STAT1 and Hepatic fibrosis: Recently, we have published the results of experiments in vitro and in different murine models of chronic liver disease showing that the non-nucleoside reverse transcriptase inhibitor (NNRTI) Rilpivirine (RPV), an antiretroviral drug widely used to treat HIV infection, selectively triggers HSC inactivation and apoptosis through signal transducer and activator of transcription (STAT)1-mediated pathways, effects that clearly attenuate liver fibrosis and promote regeneration [3].