In the context of cancer, p53 plays a crucial role in restraining cell proliferation in response to a variety of stimuli, which include factors like DNA damage, nutrient scarcity, hypoxia, and hyperproliferative signals, so this function of p53 acts as a barrier against the formation of tumors [41], earning it the well-deserved title of the guardian of the genome. This evidence concerns the gene TP53 and cancer.