TP53 and laryngotracheoesophageal cleft: On the other hand, there are some biomarkers and clinical features that can predict the likelihood of TP53 mutation in LC patients, for instance, KRAS and TP53 co-mutation, TP53 mutations in normal airway epithelium, tumor mutation burden, smoking history, imaging, and radiomics [177,178,179,180,181,182,183,184].