CD274 and central nervous system cancer: D’Arrigo et al. revealed that by using the chemical agent SAFit, which can specifically block FKBP51s’ catalytic activity [12], significant reductions were observed in PD-L1 expression and PD-L1-induced cell death in peripheral blood mononuclear cells (PBMCs) cocultured with glioma cells [10] (Figure 2).