In an effort to enhance the efficacy of carvacrol in treating periodontitis, Dao-run Hu et al. (2023) successfully modulated the Mitogen-activated protein kinase (MAPK) signaling pathway, TNF signaling pathway, and IL-17 signaling pathway by combining carvacrol with a nitrite reductase light-responsive nanodrug delivery system [38]. Here, IL17A is linked to periodontitis.