Acute respiratory SARS-CoV-2 infection generates a robust systemic cytokine response in addition to type I and type II interferon responses, and the plasma levels of IFN-α, IFN-γ, IL-1β, IL-6, and TNF-α are significantly increased in human patients with acute COVID-19 [39,40,41,42,43]. This evidence concerns the gene TNF and COVID-19.