Upon BC and CBD combination treatments, there was a significant increase in the levels of AMPK (p < 0.001), SIRT1 (p < 0.01), and PGC-1α (p < 0.01) in the sciatic nerves of the diabetic SD rats relative to the levels of these proteins in the sciatic nerves of their untreated counterparts (Figure 9C,D). The gene discussed is PPARGC1A; the disease is breast cancer.