FOXO3 and breast cancer: The BC and CBD at a dose of 30 and 15 mg/kg, respectively, for 3 weeks significantly decreased the levels of NLRP3 (p < 0.001), IL18 (p < 0.001), COX2 (p < 0.01), pNFkB (p < 0.05), and Keap1 (p < 0.001) while inducing expression of Nrf2 (p < 0.01), FOXO3a (p < 0.001) relative to their respective levels in the sciatic nerves of the diabetic animals (Figure 10C,D).