Kumar et al. 2022 showed that extracellular vesicles overexpressing miR-15a inhibited the immune evasion of colorectal cancer cells via the Lysine-specific demethylase 4B/Homeobox protein Hox-C4/Programmed death-ligand (KDM4B/HOXC4/PD-L1) axis [21]. The gene discussed is CD274; the disease is colorectal cancer.