MMP2 and neoplasm: Considering the whole process of angiogenesis in the RCC samples studied, the pathway associated with the actions of MMPs may be due to hsa-miR-15b-5p, hsa-miR-99b-5p, hsa-miR-181a-5p as they exert their role in their interactions as tumor suppressors with MMPs, especially with MMP-9 and MMP-2 (Figure 9).