Li et al., in a meta-analysis on the significance of PPARG polymorphisms in obesity and hypercholesterolemia, also showed that carriers of the G allele of the rs1801282 PPARG polymorphism had a significantly higher BMI and waist-to-hip ratio compared to the CC genotype [20]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.