Considering the significant negative correlations between SIRT1 concentration and the levels of IGF-1, the IGF-1/IGFBP-3 molar ratio and the severity of the growth deficiency, elevated SIRT1 levels may serve as one of the mechanisms through which the secretion of IGF-1 is reduced in children with short stature; however, further research is required to confirm this issue. The gene discussed is IGF1; the disease is Growth delay.