They reported that, for patients with worse outcomes, PISA correlated positively with IL-6 (r = 0.738, p < 0.001), PTX3 (r = 0.468, p = 0.008), sTWEAK (r = 0.771, p < 0.001), and Aβ 1–40 (r = 0.745, p < 0.001), suggesting a link between periodontitis, inflamed periodontal area, systemic inflammatory response, and alteration in vascular endothelial function in patients with lacunar infarcts [55]. This evidence concerns the gene PTX3 and periodontitis.