The study found no significant differences in the levels of systemic inflammation biomarkers (cytokines) with respect to periodontal condition (healthy and periodontitis), although men had higher values of IL-8 and TNF-α, which may be related to the higher left IMT values observed in men, proposing these cytokines as systemic biomarkers of susceptibility to increased IMT values. The gene discussed is TNF; the disease is periodontitis.