As shown in Figure 7C, the ESTIMATE score was negatively connected with JAM-A expression in CESC, LUAD, LAML, BRCA, ESCA, STES, KIRP, STAD, UCEC, HNSC, LUSC, THYM, THCA, TGCT, BLCA, and CHOL and positively connected with JAM-A expression in GBM, GBMLGG, LGG, SARC, SKCM-M, SKCM, PCGC, and DLBC, as shown in Figure 7D. These results suggest that JAM-A expression is closely related to immune infiltration in pan-cancer and may have distinct impacts on different types of tumors. This evidence concerns the gene F11R and cancer.