Studies on the co-activity and interaction of the SLC5A8 co-transporter with NKCC1 and KCC2 and their activity may indicate a link between changes in intracellular Na+, K+, and Cl– ion concentrations in GBM cells and the treatment effect of the drug on GBM cell ion homeostasis. This evidence concerns the gene SLC12A5 and glioblastoma.