PPARGC1A and diabetes mellitus: In 2017, Yerra et al. [222] examined the impact of isoliquiritigenin (ILQ)-induced SirT1 activation on AMP kinase and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling in the peripheral nerves of rats with DM and in neuro2a (N2A) cells subjected to elevated glucose (30 mM).